Research Areas and Activities

Bronchial Asthma: Human Studies

  • Decreased sodium-potassium and calcium adenosine triphosphatase activity in asthma: modulation by inhaled and oral corticosteroids.
  • Increased intracellular calcium and decreased activity of leukocyte sodium-potassium and calcium adenosine triphosphatase in asthma
  • Prednisolone hastens recovery from histamine-induced bronchospasm in asthmatics. J Asthma
  • Increased oxidative stress and altered levels of antioxidants in asthma
  • Increased oxidative stress in acute exacerbations of asthma.
  • Evaluative and discriminative properties of an instrument, VACCQ, to measure control of asthma
  • Predictors of emergency department use in asthmatics
  • Factors affecting attainment of control in asthma
  • Autonomic modulation in asthma
  • Comparative evaluation of quality of life, dyspnoea and lung function abnormalities in asthma and chronic obstructive pulmonary disease

Bronchial Asthma: Studies in Animal Models

  • Relationship between intracellular calcium and airway reactivity in guinea pigs
  • Effects of Vitamin E on Airway Responses and Biochemical Parameters in Guinea Pigs Sensitized to Ovalbumin.
  • Effect of sensitization on membrane ion fluxes and intracellular calcium in guinea pigs.
  • The role of inhibition of sodium-potassium adenosine triphosphatase and high dietary sodium intake was studied in a guinea pig model of asthma.
  • Potentiation of allergic asthma by exposure to Ozone and its modulation by dietary antioxidants, alpha tocopherol and ascorbic acid.

Outdoor Air Pollution

  • Ambient air pollution and chronic respiratory morbidity in Delhi.
  • Time-series study on air pollution and mortality in Delhi.

Smoking and Lung Diseases

  • Patterns of smoking in Delhi: Comparison of respiratory morbidity among Bidi and Cigarette smokers
  • Tobacco smoking in India: prevalence, quit-rates and respiratory morbidity.
  • Household environmental tobacco smoke exposure, respiratory symptoms and asthma in non-smoker adults: a multicentric population study from India.

Pulmonary Functions

  • Comparison of Bronchodilator Responsiveness in Asthma and Chronic Obstructive Pulmonary Disease
  • Expression of bronchodilator response: comparison of four indices
  • Acute bronchodilator response has limited value in differentiating bronchial asthma from COPD
  • Using arm span to estimate height: Comparative evaluation of impact of three measures of height on interpretation of spirometry.
  • Regional variations in vital capacity in adult males in India: Comparison of regression equations from four regions and impact on interpretation of spirometric data.

Chronic Obstructive Pulmonary Disease

  • Cardiovascular autonomic neuropathy in Chronic Obstructive Pulmonary Disease
  • Increased oxidative stress and altered levels of antioxidants in chronic obstructive pulmonary disease.
  • Effect of  vitamin E supplementation of standard treatment on oxidant-antioxidant status in chronic obstructive pulmonary disease.
  • Role of Mycoplasma pneumoniae infection in acute exacerbations of chronic obstructive pulmonary disease.
  • Evaluation of three scales of dyspnea in chronic obstructive pulmonary disease.
  • Abnormal heart rate recovery and chronotropic incompetence on exercise in chronic obstructive pulmonary disease.
  • Heart rate variability in Chronic Obstructive Pulmonary Disease: association with systemic inflammation and clinical implications
  • Endothelial dysfunction in chronic obstructive pulmonary disease

Interstitial Lung Diseases

  • Clinical spectrum of Idiopathic Interstitial Pneumonias
  • Management protocols for Idiopathic Interstitial Pneumonias
  • Clinical-radiolofical responses to corticosteroids in Sarcoidosis

Epidemiology of Respiratory Diseases

  • A multicentric study on epidemiology of chronic obstructive pulmonary disease and its relationship with tobacco smoking and environmental tobacco smoke exposure.
  • Prevalence and risk factors for bronchial asthma in Indian adults: a multicentre study.